The 2006 Sydney Roosters season was the 99th in the club's history. They competed in the NRL's 2006 Telstra Premiership and finished the regular season 14th (out of 15).
| Round | Opponent | Result | Syd | Opp. | Date | Venue | Crowd |
|---|---|---|---|---|---|---|---|
| 1 | South Sydney Rabbitohs | Win | 40 | 22 | Mar 14 | Aussie Stadium | |
| 2 | Melbourne Storm | Loss | 12 | 16 | Mar 19 | SFS | |
| 3 | Canberra Raiders | Win | 56 | 26 | Mar 26 | SFS | |
| 4 | Manly Sea Eagles | Loss | 22 | 30 | Apr 1 | Brookvale Oval | |
| 5 | Cronulla Sharks | Win | 28 | 24 | Apr 8 | Toyota Park | |
| 6 | Brisbane Broncos | Loss | 6 | 24 | SFS | ||
| 7 | St George-Illawarra Dragons | Loss | 12 | 22 | Apr 25 | Aussie Stadium | |
| 8 | North Queensland Cowboys | Win | 22 | 18 | Apr 29 | Dairy Farmers Stadium |
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